IDENTIFICATION OF DEGRADATION PRODUCTS OF SOME CHEMICAL WARFARE AGENTS BY CAPILLARY ELECTROPHORESIS IONSPRAY MASS-SPECTROMETRY

被引:64
作者
KOSTIAINEN, R [1 ]
BRUINS, AP [1 ]
HAKKINEN, VMA [1 ]
机构
[1] UNIV HELSINKI,DEPT CHEM,SF-00100 HELSINKI,FINLAND
来源
JOURNAL OF CHROMATOGRAPHY | 1993年 / 634卷 / 01期
关键词
D O I
10.1016/0021-9673(93)80318-3
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Capillary zone electrophoresis-ionspray mass spectrometry (CZE-IS-MS) in the negative-ion mode was applied in the identification of five organophosphonic acids, which are the primary hydrolysis products of nerve agents. The spectra exhibit a very abundant (M - H)- ion with minimal fragmentation. Fragment ions were produced by raising the nozzle - skimmer voltage difference in the first vacuum stage between the atmospheric pressure ion source and the mass analyzer. CZE-IS-MS provides extremely good separation efficiency and very high sensitivity for the phosphonic acids. Sensitivity in the range 10-30 pg was achieved with standard solutions using selected ion monitoring. Linear regression analysis data showed correlation coefficients to be between 0.994 and 0.999, indicating good quantitative linearity of the method.
引用
收藏
页码:113 / 118
页数:6
相关论文
共 25 条
  • [1] ALEKSANDROV ML, 1984, ZH ANAL KHIM, V40, P1570
  • [2] ANDERSSON G, 1983, PHOSPHORUS SULFUR, V18, P485
  • [3] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ANALYSIS OF ALKYL METHYLPHOSPHONIC ACIDS BY DERIVATIZATION
    BOSSLE, PC
    MARTIN, JJ
    SARVER, EW
    SOMMER, HZ
    [J]. JOURNAL OF CHROMATOGRAPHY, 1983, 267 (01): : 209 - 212
  • [4] ION SPRAY INTERFACE FOR COMBINED LIQUID CHROMATOGRAPHY/ATMOSPHERIC PRESSURE IONIZATION MASS-SPECTROMETRY
    BRUINS, AP
    COVEY, TR
    HENION, JD
    [J]. ANALYTICAL CHEMISTRY, 1987, 59 (22) : 2642 - 2646
  • [5] STRUCTURAL CHARACTERIZATION OF PROTEIN TRYPTIC PEPTIDES VIA LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY AND COLLISION-INDUCED DISSOCIATION OF THEIR DOUBLY CHARGED MOLECULAR-IONS
    COVEY, TR
    HUANG, EC
    HENION, JD
    [J]. ANALYTICAL CHEMISTRY, 1991, 63 (13) : 1193 - 1200
  • [6] ANALYSIS OF PHOSPHORUS-CONTAINING HYDROLYTIC PRODUCTS OF ORGANOPHOSPHORUS INSECTICIDES IN WATER
    DAUGHTON, CG
    CROSBY, DG
    GARNAS, RL
    HSIEH, DPH
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1976, 24 (02) : 236 - 241
  • [7] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    FENN, JB
    MANN, M
    MENG, CK
    WONG, SF
    WHITEHOUSE, CM
    [J]. SCIENCE, 1989, 246 (4926) : 64 - 71
  • [8] DERIVATIVES FOR CHARACTERIZATION OF ALKYL-PHOSPHONATES AND AMINO-PHOSPHONATES ALKYLPHOSPHONATES BY GAS-CHROMATOGRAPHY AND GAS CHROMATOGRAPHY MASS SPECTROMETRY
    HARVEY, DJ
    HORNING, MG
    [J]. JOURNAL OF CHROMATOGRAPHY, 1973, 79 (MAY16): : 65 - 74
  • [9] HIRSJRVI P, 1981, TRACE ANAL CHEM WARF, V1, P27
  • [10] ONLINE FLAME PHOTOMETRIC DETECTION IN MICRO-COLUMN LIQUID-CHROMATOGRAPHY
    KIENTZ, CE
    VERWEIJ, A
    BOTER, HL
    POPPEMA, A
    FREI, RW
    DEJONG, GJ
    BRINKMAN, UAT
    [J]. JOURNAL OF CHROMATOGRAPHY, 1989, 467 (02): : 385 - 394