INHIBITION OF DUCK HEPATITIS-B VIRUS-DNA REPLICATION BY ANTIVIRAL CHEMOTHERAPY WITH GANCICLOVIR NALIDIXIC-ACID

被引：18

作者：

WANG, YY

LUSCOMBE, C

BOWDEN, S

SHAW, T

LOCARNINI, S

机构：

[1] FAIRFIELD HOSP,VICTORIAN INFECT DIS REFERENCE LAB,FAIRFIELD,VIC 3078,AUSTRALIA

[2] FAIRFIELD HOSP,MACFARLANE BURNET CTR MED RES,FAIRFIELD,VIC 3078,AUSTRALIA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 02期

关键词：

D O I：

10.1128/AAC.39.2.556

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this study was to examine the effects of ganciclovir and nalidixic acid either alone or in combination on duck hepatitis B virus DNA replication in vivo with particular reference to production of viral supercoiled DNA and RNA. The most effective antiviral response was observed in the livers of ducks treated by the combination therapy for 28 days, which resulted in a substantial decrease in the amounts of viral supercoiled DNA, relaxed circular and single-stranded DNA, and also viral RNA. This combination treatment was not hepatotoxic over the study period.

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页码：556 / 558

页数：3

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