PULSATILE INSULIN-SECRETION ACCOUNTS FOR 70-PERCENT OF TOTAL INSULIN-SECRETION DURING FASTING

被引:128
作者
PORKSEN, N
MUNN, S
STEERS, J
VORE, S
VELDHUIS, J
BUTLER, P
机构
[1] MAYO CLIN, ENDOCRINE RES UNIT, ROCHESTER, MN 55905 USA
[2] MAYO CLIN, DIV TRANSPLANT SURG, ROCHESTER, MN 55905 USA
[3] UNIV VIRGINIA, DEPT MED, CHARLOTTESVILLE, VA 22908 USA
[4] NATL SCI FDN, CTR BIOL TIMING, CHARLOTTESVILLE, VA 22908 USA
[5] E CAROLINA SCH MED, DEPT COMPARAT MED, GREENVILLE, NC 27858 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1995年 / 269卷 / 03期
关键词
PULSATILITY; DIABETES MELLITUS; DECONVOLUTION; VALIDATION;
D O I
10.1152/ajpendo.1995.269.3.E478
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of the present study was to determine the contributions of discrete insulin secretory bursts vs. basal insulin release to total insulin secretion in vivo. Quantification of the partitioning of pulsatile and basal insulin secretion is complicated by physiological delivery of these pulses into the portal vein and the absence of validated methods of measuring the rates of pulsatile and basal insulin secretion in vivo. We therefore 1) developed a canine model with chronically implanted portal vein catheters, 2) validated an established deconvolution technique as well as a novel direct catheterization technique (Clustcath) for measurement of pulsatile and nonpulsatile insulin secretion rates in this model, and 3) applied these methods to study insulin secretion in the overnight-fasted dog in vivo to determine the contribution of pulsatile vs. basal insulin secretion to total rates of endogenous insulin secretion. Rates of total, pulsatile, and nonpulsatile endogenous insulin secretion measured by Clustcath closely parallel those measured by deconvolution analysis (54 +/- 15 vs. 51 +/- 11, 38 +/- 12 vs. 36 +/- 11, and 16 +/- 4 vs. 14 +/- 4 pmol/min, respectively). Clustcath and deconvolution indicated that the majority of insulin was secreted as pulses (70 +/- 6 and 66 +/- 7%, respectively). These data infer that any process that selectively decreases the pulsatile component of insulin secretion (e.g., diabetes mellitus) will likely have a major impact on total insulin secretion.
引用
收藏
页码:E478 / E488
页数:11
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