FELINE HERPESVIRUS TYPE-1 GLYCOPROTEINS ELICITING VIRUS NEUTRALIZING AND HEMAGGLUTINATION-INHIBITING ANTIBODIES

被引：33

作者：

HORIMOTO, T ^{[1
]}

LIMCUMPAO, JA ^{[1
]}

TOHYA, Y ^{[1
]}

TAKAHASHI, E ^{[1
]}

MIKAMI, T ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR,DEPT VET MICROBIOL,YAYOI 1-1-1,BUNKYO KU, TOKYO 113, JAPAN

来源：

ARCHIVES OF VIROLOGY | 1990年 / 111卷 / 1-2期

关键词：

D O I：

10.1007/BF01310510

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monoclonal antibodies (MoAbs) to feline herpesvirus type 1 (FHV-1) were produced to identify the virus-specified immunogenic proteins. When antigens recognized by the MoAbs were investigated by immunoblot and immunoprecipitation assays using FHV-1-infected cell lysate, four groups of immunogenic proteins were identified. MoAbs directed against 60 kDa, 113 kDa, and 143 kDa/108 kDa glycoproteins had virus neutralizing activities, but those against 170 kDa protein did not. Furthermore, MoAbs to the 60 kDa glycoprotein also showed hemagglutination-inhibition activity, indicating that this glycoprotein might be the hemagglutinin. © 1990 Springer-Verlag.

引用

页码：127 / 132

页数：6

共 10 条

[1]

COMPTON T, 1989, UCLA S MOL CELLULAR, V90, P45

[2]

CRANDELL RA, 1958, P SOC EXP BIOL MED, V97, P487, DOI 10.3181/00379727-97-23783

[3] BIOCHEMICAL-STUDY OF THE FELINE HERPESVIRUS-1 - IDENTIFICATION OF GLYCOPROTEINS BY AFFINITY [J].