CORRELATION OF PARTITIONING OF NITROIMIDAZOLES IN THE NORMAL-OCTANOL SALINE AND LIPOSOME SYSTEMS WITH PHARMACOKINETIC PARAMETERS AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS (QSAR)

被引：31

作者：

BETAGERI, GV ^{[1
]}

ROGERS, JA ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC PHARM & PHARMACEUT SCI,EDMONTON T6G 2N8,ALBERTA,CANADA

来源：

PHARMACEUTICAL RESEARCH | 1989年 / 6卷 / 05期

关键词：

D O I：

10.1023/A:1015931431817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：399 / 403

页数：5

共 27 条

[1] ELECTRON-AFFINIC SENSITIZATION .7. CORRELATION BETWEEN STRUCTURES ONE-ELECTRON REDUCTION POTENTIALS, AND EFFICIENCIES OF NITROIMIDAZOLES AS HYPOXIC CELL RADIOSENSITIZERS [J].

ADAMS, GE ;

FLOCKHART, IR ;

SMITHEN, CE ;

STRATFORD, IJ ;

WARDMAN, P ;

WATTS, ME .

RADIATION RESEARCH, 1976, 67 (01) :9-20

[2]

AHMED MS, 1985, PHARMACEUT RES, V2, P119

[3] THERMODYNAMICS OF DISTRIBUTION OF PARA-SUBSTITUTED PHENOLS BETWEEN AQUEOUS-SOLUTION AND ORGANIC-SOLVENTS AND PHOSPHOLIPID-VESICLES [J].

ANDERSON, NH ;

DAVIS, SS ;

JAMES, M ;

KOJIMA, I .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (04) :443-448

[4] THE LIPOSOME AS A DISTRIBUTION MODEL IN QSAR STUDIES [J].

BETAGERI, GV ;

ROGERS, JA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 46 (1-2) :95-102

[5] THERMODYNAMICS OF PARTITIONING OF BETA-BLOCKERS IN THE NORMAL-OCTANOL-BUFFER AND LIPOSOME SYSTEMS [J].

BETAGERI, GV ;

ROGERS, JA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (2-3) :165-173

[6]

BETAGERI GV, 1987, 2ND NAT M AAPS BOST

[7]

BROWN JM, 1981, INT J RADIAT ONCOL, V7, P695

[8] PARTITION-COEFFICIENT AS A GUIDE TO THE DEVELOPMENT OF RADIOSENSITIZERS WHICH ARE LESS TOXIC THAN MISONIDAZOLE [J].

BROWN, JM ;

WORKMAN, P .

RADIATION RESEARCH, 1980, 82 (01) :171-190

[9]

BROWN RE, 1984, QSAR DES BIOACT COMP, P13

[10]

CHAPMAN JD, 1988, IN PRESS INT J RAD O

← 1 2 3 →