GLUTAMATE RELEASE AND PRESYNAPTIC ACTION OF AP4 DURING INSPIRATORY DRIVE TO PHRENIC MOTONEURONS

被引：19

作者：

GREER, JJ ^{[1
]}

SMITH, JC ^{[1
]}

FELDMAN, JL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT KINESIOL,SYST NEUROBIOL LAB,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1992年 / 576卷 / 02期

关键词：

RESPIRATION; PHRENIC MOTONEURON; GLUTAMATE; DL-2-AMINO-4-PHOSPHONOBUTYRATE; EXCITATORY AMINO ACID; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1016/0006-8993(92)90705-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High-performance liquid chromatography (HPLC) was used to detect the presence of excitatory amino acids released from bulbospinal axon terminals projecting to cervical spinal respiratory motoneurons during transmission of inspiratory drive in an in vitro neonatal rat brain-stem-spinal cord preparation. Measurements were then repeated under paradigms where transmitter release was decreased by either depression of bulbospinal respiratory drive, or by adding DL-2-amino-4-phosphonobutyrate (AP4) to the solution bathing the spinal cord. The amounts of glutamate, but not aspartate, released decreased significnatly with depressed brainstem inspiratory drive or the activation of AP4-sensitive receptors within the cervical (C) spinal cord.

引用

页码：355 / 357

页数：3

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