CHANGES IN THE STABILITY OF SPECIFIC MESSENGER-RNA SPECIES IN RESPONSE TO GROWTH STAGE IN BACILLUS-SUBTILIS

被引：44

作者：

RESNEKOV, O

RUTBERG, L

VONGABAIN, A

机构：

[1] KAROLINSKA INST,DEPT BACTERIOL,POB 60400,S-10401 STOCKHOLM 60,SWEDEN

[2] UNIV LUND,DEPT MICROBIOL,S-22362 LUND,SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 21期

关键词：

aprE; cell differentiation; mRNA decay; posttranscriptional control; succinate dehydrogenase;

D O I：

10.1073/pnas.87.21.8355

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study we compared the cellular concentrations and stability of the mRNA transcribed from the aprE (subtilisin) gene (a gene preferentially expressed in stationary growth phase) with those of a vegetative mRNA, succinate dehydrogenase (SDH) mRNA. The subtilisin transcript was shown to be at least 3 times more stable in early stationary phase than it is 2 hr further into stationary phase. When cells were shifted from maximum expression of the subtilisin transcript in stationary phase to physiological conditions, which allowed for the resumption of vegetative growth, the cellular concentration of the subtilisin mRNA decreased rapidly. We conclude that mRNA degradation is one of the means by which the cellular concentrations of the SDH and subtilisin transcripts are adjusted in response to growth stage.

引用

页码：8355 / 8359

页数：5

共 29 条

[1] BIOSYNTHESIS AND STABILITY OF GLOBIN MESSENGER-RNA IN CULTURED ERYTHROLEUKEMIC FRIEND CELLS [J].