STUDIES ON ANTIULCER DRUGS .2. SYNTHESIS AND ANTIULCER ACTIVITIES OF IMIDAZO[1,2-A]PYRIDINYL-2-ALKYLAMINOBENZOXAZOLES AND 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINYL DERIVATIVES

被引：64

作者：

KATSURA, Y ^{[1
]}

NISHINO, S ^{[1
]}

INOUE, Y ^{[1
]}

TOMOI, M ^{[1
]}

TAKASUGI, H ^{[1
]}

机构：

[1] FUJISAWA PHARMACEUT CO LTD, PROD DEV LABS, OSAKA 532, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期

关键词：

ANTISTRESS ULCER ACTIVITY; ETHANOL-INDUCED GASTRIC LESION; CYTOPROTECTIVE ACTIVITY; IMIDAZO[1,2-A]PYRIDINYLBENZOXAZOLE; 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINYLBENZOXAZOLE; SUCRALFATE; CIMETIDINE; RANITIDINE; STRUCTURE-ACTIVITY RELATIONSHIP;

D O I：

10.1248/cpb.40.371

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of imidazo[1,2-a]pyridinylbenzoxazoles (4) and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinylbenzoxazoles (5) were synthesized and tested for anti-stress ulcer activity in rats. Several compounds were found to be more active than the reference compounds, sucralfate, cimetidine and ranitidine. Some of them exhibited potent protective activity against ethanol-induced gastric lesion. The synthesis and structure-activity relationships of these compounds are discussed.

引用

页码：371 / 380

页数：10

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