ROLE OF BACTERIAL CYTOTOXINS IN HEMOLYTIC UREMIC SYNDROME AND THROMBOTIC THROMBOCYTOPENIC PURPURA

被引：8

作者：

ASHKENAZI, S ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

来源：

ANNUAL REVIEW OF MEDICINE | 1993年 / 44卷

关键词：

SHIGELLA; ESCHERICHIA-COLI; SHIGA-LIKE TOXINS;

D O I：

10.1146/annurev.med.44.1.11

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bacterial cytotoxins, which are produced by Shigella dysenteriae 1 and certain E. coli serotypes, kill mammalian cells by inhibiting protein synthesis. They have been related to hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, probably by initial insult to vascular endothelial cells. This insight opened new avenues of research and possible interventions.

引用

页码：11 / 18

页数：8

共 33 条

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