RESTRUCTURING OF THE BLEOMYCIN METAL CORE - NOVEL OXYGEN-ACTIVATING LIGANDS WITH SYMMETRIZED STRUCTURE

被引：24

作者：

OTSUKA, M

SATAKE, H

SUGIURA, Y

MURAKAMI, S

SHIBASAKI, M

KOBAYASHI, S

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)61368-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel ligands having symmetrized coordination environment consisting of two histidine units and a pyridine are prepared. Oxygen activating efficiency of the iron complexes of the synthetic ligands increases by introducing electron donating substituent into the pyridine ring.

引用

页码：8497 / 8500

页数：4

共 16 条

[1] A SURVEY OF HAMMETT SUBSTITUENT CONSTANTS AND RESONANCE AND FIELD PARAMETERS
HANSCH, C
LEO, A
TAFT, RW
[J]. CHEMICAL REVIEWS, 1991, 91 (02) : 165 - 195
[2] THE CHEMISTRY OF ACTIVATED BLEOMYCIN
HECHT, SM
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1986, 19 (12) : 383 - 391
[3] HIRAO T, 1990, SYNLETT, P541
[4] KITTAKA A, 1988, TETRAHEDRON, V44, P2811
[5] BLEOMYCIN METAL SITE MODELS WITH APICAL IMIDAZOLE OR SULFHYDRYL DONORS
LOMIS, TJ
SIUDA, JF
SHEPHERD, RE
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (04) : 290 - 292
[6] LOMIS TJ, 1989, INORG CHEM, V28, P2367
[7] ELECTRONIC SUBSTITUENT EFFECT OF NITROGEN LIGANDS IN CATALYTIC ASYMMETRIC HYDROSILYLATION OF KETONES - CHIRAL 4-SUBSTITUTED BIS(OXAZOLINYL)PYRIDINES
NISHIYAMA, H
YAMAGUCHI, S
KONDO, M
ITOH, K
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (15) : 4306 - 4309
[8] OHNO M, 1990, RECENT PROGRESS IN THE CHEMICAL SYNTHESIS OF ANTIBIOTICS, P387
[9] OHNO M, 1987, STEREOCHEMISTRY ORGA, P147
[10] OHNO M, IN PRESS STEREOCONTR

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