ANTIOXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN BY MORIN HYDRATE

被引：22

作者：

WU, TW ^{[1
]}

FUNG, KP ^{[1
]}

YANG, CC ^{[1
]}

WEISEL, RD ^{[1
]}

机构：

[1] TORONTO HOSP,TORONTO,ON M5G 2C4,CANADA

来源：

LIFE SCIENCES | 1995年 / 57卷 / 03期

关键词：

LOW DENSITY LIPOPROTEIN OXIDATION; MORIN; ATHEROSCLEROSIS;

D O I：

10.1016/0024-3205(95)00274-A

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at 100 mu M concentration, effectively inhibits Cu2+- induced oxidation of LDL. The oxidation of LDL was assessed by agarose gel electrophoresis. This was further studied by measuring the increased values of the malondialdehyde equivalents and the decreased numbers of reactive amino groups on oxidized LDL. Trolox, at equimolar concentrations, exhibit similar effects in preventing oxidation of LDL.

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页码：PL51 / PL56

页数：6

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