HIGH-DENSITY CELL-CULTURE BY MEMBRANE-BASED CELL RECYCLE

被引：56

作者：

CHANG, HN ^{[1
]}

YOO, IK ^{[1
]}

KIM, BS ^{[1
]}

机构：

[1] KOREA ADV INST SCI & TECHNOL, BIOPROC RES CTR, TAEJON 305701, SOUTH KOREA

来源：

BIOTECHNOLOGY ADVANCES | 1994年 / 12卷 / 03期

关键词：

HIGH DENSITY CELL CULTURE; CELL RECYCLE; CELL RETENTION; BIOREACTORS;

D O I：

10.1016/0734-9750(94)90020-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enhancement of productivity of a bioprocess necessitates continuous operation of bioreactors with high biomass concentrations than are possible in conventional batch, fed-batch or continuous modes of culture. Membrane-based cell recycle has been effectively used to maintain high cell concentrations in bioreactors. This review compares membrane-based cell recycle operation with other such high density cell culture systems as immobilized cell reactors and reactors with cell recycle by centrifugation or gravity sedimentation. A theoretical of production of primary and secondary metabolites in membrane-based recycle systems is presented. Operation of this type of system is discussed with examples from aerobic and anaerobic fermentations.

引用

页码：467 / 487

页数：21

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