PROPERTIES OF A GENERAL-MODEL OF DNA EVOLUTION UNDER NO-STRAND-BIAS CONDITIONS

被引：136

作者：

LOBRY, JR

机构：

[1] Laboratoire de Biométrie, CNRS URA 243, Université Claude Bernard, Villeurbanne, F-69622

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1995年 / 40卷 / 03期

关键词：

DNA EVOLUTION; NO-STRAND BIAS; CODING SEQUENCE;

D O I：

10.1007/BF00163237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under the hypothesis of no-strand-bias conditions, the Watson and Crick base-pairing rule decreases the complexity of models of DNA evolution by reducing to six the maximum number of substitution rates. It was shown that intrastrand equimolarity between A and T (A* T*) and between G and C (G* C*) is a general asymptotic property of this class of models. This statistical prediction was observed on 60 long genomic fragments (>50 kbp) from various kingdoms, even when the effect of the two opposite orientations for coding sequences is removed. The practical consequence of the model for estimating the expected number of substitutions per site between two homologous DNA sequences is discussed.

引用

页码：326 / 330

页数：5

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