CODOMINANT EFFECTS OF THE FATTY (FA) GENE DURING EARLY DEVELOPMENT OF OBESITY

被引:27
作者
TRUETT, GE [1 ]
TEMPELMAN, RJ [1 ]
WALKER, JA [1 ]
机构
[1] LOUISIANA STATE UNIV, DEPT EXPTL STAT, BATON ROUGE, LA 70803 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1995年 / 268卷 / 01期
关键词
ZUCKER RAT; GROWTH; GENETICS; HETEROZYGOTE EFFECTS; ADIPOSE TISSUE;
D O I
10.1152/ajpendo.1995.268.1.E15
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Expression of a single copy of the rat obesity fatty (fa) gene may affect energy balance. To test this hypothesis, the effects of zero, one, and two copies of fa on early growth were evaluated, using a molecular genetic method for counting fa alleles inherited by 7- and 14-day-old F-2 offspring of a BN/Crl x Crl:ZUC-fa F-1 intercross. Litter and sex effects were controlled by multiple-regression analysis, allowing genotype effects on the weights of body, inguinal adipose pads, interscapular brown adipose tissue, and liver to be isolated. At 7 days of age, the fa copy number had linear effects on body and inguinal adipose pads weight. At 14 days of age, the fa copy number had linear effects on body, inguinal adipose pads, and interscapular brown adipose tissue weights and an additional quadratic effect on inguinal adipose pads weight. Thus fa has codominant effects on growth during the first week of life. The recessive effects of fa on growth appear during the second week of life.
引用
收藏
页码:E15 / E20
页数:6
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