Biological or genetic modulation of intervertebral disk degeneration

被引：12

作者：

Wang, Jeffrey C. ^{[1
]}

Kim, Joseph S. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, UCLA Comprehens Spine Ctr, Sch Med, Los Angeles, CA 90404 USA

来源：

CURRENT ORTHOPAEDIC PRACTICE | 2008年 / 19卷 / 04期

关键词：

cell therapy; gene therapy; growth factor; intervertebral disk; tissue engineering;

D O I：

10.1097/BCO.0b013e3282f82d34

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Purpose of review The purpose of this review is to provide an organized overview of the current literature regarding novel biological strategies for treating intervertebral disk degeneration. Recent findings The new biological treatments involve three basic approaches: protein therapy, gene therapy, and cell therapy. Recent studies have demonstrated the potential of each approach in modulating the biology of the intervertebral disk. Summary Although these studies have established the theoretical benefits of biological modulation, significant work remains to be accomplished before human clinical trials can be considered.

引用

页码：366 / 371

页数：6

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