ACTH AND CORTISOL SECRETION IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：17

作者：

FRANCESCHI, M ^{[1
]}

AIRAGHI, L ^{[1
]}

GRAMIGNA, C ^{[1
]}

TRUCI, G ^{[1
]}

MANFREDI, MG ^{[1
]}

CANAL, N ^{[1
]}

CATANIA, A ^{[1
]}

机构：

[1] UNIV MILAN,SCH MED,MED CLIN 1,I-20122 MILAN,ITALY

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 09期

关键词：

D O I：

10.1136/jnnp.54.9.836

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The "glucocorticoid cascade hypothesis" for pathological ageing of the brain is supported by strong experimental data, but the clinical correlates are far less clear. The basal ACTH and cortisol secretion have been studied before and after the dexamethasone suppression test in patients in the early stages of clinically probable Alzheimer's disease and in controls, and the results were all normal. These findings do not support the hypothesis that the pathological brain ageing of Alzheimer's type is caused by hyperactivity of the pituitary-adrenal axis.

引用

页码：836 / 837

页数：2

共 13 条

[1] DEXAMETHASONE SUPPRESSION TEST AND SERUM PROLACTIN IN DEMENTIA DISORDERS [J].