THE EFFECTS OF INTERLEUKIN-4 AND INTERLEUKIN-5 ON THE DIFFERENTIATION OF B-CELLS FROM (NZBXNZW)F1 MICE

被引:6
作者
ALARCONRIQUELME, ME
MOLLER, G
FERNANDEZ, C
机构
[1] Department of Immunology, Arrhenius Laboratories for Natural Sciences, Stockholm University
关键词
D O I
10.1111/j.1365-3083.1991.tb03742.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe here that IL-4 and IL-5 together can induce the production of high amounts of IgG1 polyclonal antibodies by B cells from old (NZB x NZW)F1 mice even in the absence of LPS. The effect was less marked in young mice from the same strain or in normal Balb/c mice. The cells sensitive to the treatment with the interleukins were the large B cells. Old mice had higher proportions of such cells than young mice or normal Balb/c mice. Synthesis of anti-DNA antibodies of the IgM class was induced. Although IL-4 plus IL-5 induced a strong polyclonal IgG1 production, there were no IgG1 anti-DNA antibodies.
引用
收藏
页码:119 / 129
页数:11
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