ASYMMETRIC PALLADIUM-CATALYZED ALLYLIC SUBSTITUTION USING PHOSPHORUS-CONTAINING OXAZOLINE LIGANDS

被引：492

作者：

DAWSON, GJ

FROST, CG

WILLIAMS, JMJ

机构：

[1] LOUGHBOROUGH UNIV TECHNOL,DEPT CHEM,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND

[2] GLAXO GRP RES LTD,WARE SG10 0DJ,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)93403-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new phosphorus-containing oxazoline ligands has been developed. The use of these ligands for asymmetric palladium catalysed allylic substitution of 1,3-diphenylprop-2-enyl-1-acetate 12 with the sodium salt of dimethylmalonate has been achieved with 90 - 94% ee and 88 - 99% yield.

引用

页码：3149 / 3150

页数：2

共 10 条

[1]

AKERMARK B, 1987, J ORGANOMET CHEM, V335, P133

[2] SYNTHESIS OF OPTICALLY-ACTIVE BIS(2-OXAZOLINES) - CRYSTAL-STRUCTURE OF A 1,2-BIS(2-OXAZOLINYL)BENZENE.ZNCL2 COMPLEX [J].