PREFERENTIAL INVOLVEMENT OF 11Q23-24 AND 11P15 IN BREAST-CANCER

被引：26

作者：

FERTIPASSANTONOPOULOU, A ^{[1
]}

PANANI, AD ^{[1
]}

RAPTIS, S ^{[1
]}

机构：

[1] UNIV ATHENS,EVANGELISMOS MED CTR,DEPT INTERNAL MED 2,GR-10676 ATHENS,GREECE

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 51卷 / 02期

关键词：

D O I：

10.1016/0165-4608(91)90130-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty cases of breast cancer were cytogenetically studied by G-banding using direct tumor preparations. Among them 20 cases exhibited abnormalities of the long and/or short arm of chromosome 11. Thus, 11q was involved in 16 cases and 11p in ten cases. There was consistent involvement of bands 11q23-24 (15 cases) and 11p15 (9 cases), where the cellular oncogenes ets and H-ras 1, respectively, are located. These findings suggest that involvement of bands 11q23-24 and 11p15 may be specific in a group of breast cancers, leading to the activation of cellular oncogenes or loss of cancer suppressor genes.

引用

页码：183 / 188

页数：6

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