MOLECULAR MODELING STUDIES ON 1,4-DIHYDROPYRIDINES ACTING AT THE CA-CHANNEL

被引：13

作者：

HOLTJE, HD

机构：

[1] Institute of Pharmacy, Free University of Berlin, Berlin, W-1000

来源：

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1992年 / 11卷 / 02期

关键词：

CA-CHANNEL MODULATORS; MOLECULAR MODELING; TISSUE SELECTIVITY; PHARMACOPHORE MODEL; 1,4-DIHYDROPYRIDINES;

D O I：

10.1002/qsar.19920110219

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using molecular modelling techniques, we have compared structural features of a series of 1,4-dihydropyridine calcium-channel blockers. Computer graphics modelling suggests that the agonistic as well as the antagonistic behaviour is controlled by substituents at the C-5 of the DHP-system. whereas differences in phenyl ring substitution may influence tissue selectivity and negative inotropic activity of the compounds.

引用

页码：224 / 227

页数：4

共 13 条

[1]

BERNTSSON P, J CARDIOVASC PHAR S1, V10, pS60

[2]

BOYD RA, 1987, J PHARMACOL EXP THER, V243, P118

[3] THE OPTICAL ISOMERS OF THE 1,4-DIHYDROPYRIDINE BAY K-8644 SHOW OPPOSITE EFFECTS ON CA CHANNELS [J].