RADIATION RESPONSE OF THE RAT CERVICAL SPINAL-CORD AFTER IRRADIATION AT DIFFERENT AGES - TOLERANCE, LATENCY AND PATHOLOGY

被引:43
作者
RUIFROK, ACC [1 ]
STEPHENS, LC [1 ]
VANDERKOGEL, AJ [1 ]
机构
[1] CATHOLIC UNIV NIJMEGEN,INST RADIOTHERAPY,6500 HB NIJMEGEN,NETHERLANDS
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1994年 / 29卷 / 01期
关键词
RADIATION MYELOPATHY; SPINAL CORD; RADIATION DAMAGE; AGE; LATE EFFECTS; HISTOPATHOLOGY;
D O I
10.1016/0360-3016(94)90228-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The investigation of the age dependent single-dose radiation tolerance, latency to radiation myelopathy, and the histopathological changes after irradiation of the rat cervical spinal cord. Methods and Materials: Rats, ages 1-18 weeks, were irradiated with graded single doses of 4 MV photons to the cervical spinal cord. When the rats showed definite signs of paresis of the forelegs, they were killed and processed for histological examination. Results: The radiation dose resulting in paresis due to white matter damage in 50% of the animals (ED(50)) after single dose irradiation was about 21.5 Gy at all ages greater than or equal to 2 weeks (mean 21.4 Gy; 95% CI 21.0, 21.7 Gy). Only the ED(50) at 1 week was significantly lower (19.5 Gy; 18.7, 20.3 Gy). The latency to the development of paresis clearly changed with the age at irradiation, from about 2 weeks after irradiation at 1 week to 6-8 months after irradiation at age greater than or equal to 8 weeks. The white matter damage was similar in all symptomatic animals studied. The most prominent were areas with diffuse demyelination and swollen axons, often with focal necrosis, accompanied by glial reaction. This was observed in all symptomatic animals, irrespective of the age at irradiation. Expression of vascular damage appeared to depend on the age at irradiation. No vascular damage was observed in the rats irradiated at 1 week, clearly altered blood vessels were seen in animals symptomatic 10 weeks after irradiation at greater than or equal to 3 weeks, and vascular necrosis occurred after greater than or equal to 6 months in some rats irradiated at greater than or equal to 8 weeks. Conclusion: Although the latency to myelopathy is clearly age dependent, single dose tolerance is not age dependent at age greater than or equal to 2 weeks in the rat cervical spinal cord. The white matter damage is similar in all symptomatic animals studied, but the vasculopathies appear to be influenced by the age at irradiation. It is concluded that white matter damage and vascular damage are separate phenomena contributing to the development of radiation myelopathy, expression of which may depend on the radiation dose applied and the age at irradiation.
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页码:73 / 79
页数:7
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