DECREASED GLUTATHIONE-PEROXIDASE ACTIVITY IN SCIATIC-NERVE OF ALLOXAN-INDUCED DIABETIC MICE AND ITS CORRELATION WITH BLOOD-GLUCOSE LEVELS

被引：47

作者：

HERMENEGILDO, C ^{[1
]}

RAYA, A ^{[1
]}

ROMA, J ^{[1
]}

ROMERO, FJ ^{[1
]}

机构：

[1] UNIV VALENCIA, DEPT PHYSIOL, EXPTL TOXICOL & NEUROTOXICOL UNIT, E-46010 VALENCIA, SPAIN

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 08期

关键词：

GLUTATHIONE PEROXIDASE; DIABETIC NEUROPATHY; DIABETES; ALLOXAN; MICE; SCIATIC NERVE; HYPERGLYCEMIA; ANTIOXIDANTS;

D O I：

10.1007/BF00998274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of alloxan-induced diabetes on glutathione peroxidase (GSH-Px) activity in sciatic nerve of mice has been studied. We have found, 7 days after alloxan treatment, a significant decrease in this enzymatic activity in the cytosol of sciatic nerve of diabetic mice, and moreover, that these changes remained unaltered up to 21 days after alloxan injection. No modification in the glutathione content of sciatic nerve of diabetic mice was observed throughout the experiment when compared with controls. The decrease in GSH-Px activity in this tissue shows a good correlation with the increase of blood glucose levels throughout the experiment. It is hypothesized whether a combination of mechanisms could be involved in this decrease of GSH-Px activity and if oxygen radicals might be the common mediators of these processes.

引用

页码：893 / 896

页数：4

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