ISOLATION OF A MONOCLONAL-ANTIBODY WHICH BLOCKS VACCINIA VIRUS-INFECTION

被引：20

作者：

CHANG, W

HSIAO, JC

CHUNG, CS

BAIR, CH

机构：

[1] CHINESE CULTURE UNIV, INST BIOTECHNOL, TAIPEI, TAIWAN

[2] NATL DEF MED CTR, GRAD INST LIFE SCI, TAIPEI, TAIWAN

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 01期

关键词：

D O I：

10.1128/JVI.69.1.517-522.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have isolated a monoclonal antibody, B2, that neutralizes vaccinia virus infection. B2 reacts with a trypsin-sensitive cell surface epitope. B2 does not neutralize infection of herpes simplex virus, suggesting that the B2-reactive epitope is specifically involved in vaccinia virus entry, A survey of 12 different cell lines reveals a correlation between B2 reactivity and susceptibility to vaccinia virus infection. In addition, B2 interferes with vaccinia virus adsorption to target cells. Taken together, the B2-reactive epitope is part of a receptor that appears important for vaccinia virus entry.

引用

页码：517 / 522

页数：6

共 42 条

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