SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES .31. INHIBITORY EFFECTS OF 2'-DEOXY-5-STYRYLURIDINE 5'-TRIPHOSPHATE ANALOGS ON RETROVIRAL REVERSE TRANSCRIPTASES AND HIGHER EUKARYOTIC DNA-POLYMERASES

被引：2

作者：

YAMAGUCHI, T

IZUTA, S

SUZUKI, M

YOSHIDA, S

MATSUKAGE, A

SANEYOSHI, M

机构：

[1] NAGOYA UNIV,SCH MED,DIS MECHANISM & CONTROL RES INST,CANC CELL BIOL LAB,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] AICHI CANC CTR,RES INST,CELL BIOL LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 6-7期

关键词：

D O I：

10.1080/15257779408012149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some new 5'-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3'-dideoxyUTP analogues.

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页码：1247 / 1258

页数：12

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