COLOCALIZATION OF TRANSFORMING GROWTH FACTOR-BETA-2 WITH ALPHA-1(I) PROCOLLAGEN MESSENGER-RNA IN TISSUE-SECTIONS OF PATIENTS WITH SYSTEMIC-SCLEROSIS

被引：195

作者：

KULOZIK, M ^{[1
]}

HOGG, A ^{[1
]}

LANKATBUTTGEREIT, B ^{[1
]}

KRIEG, T ^{[1
]}

机构：

[1] UNIV MUNICH,DERMATOL KLIN & POLIKLIN,DEPT DERMATOL,FRAUENLOBSTR 9-11,W-8000 MUNICH 2,GERMANY

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 86卷 / 03期

关键词：

collagen synthesis; fibrosis; systemic sclerosis; TTS-beta;

D O I：

10.1172/JCI114793

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of transforming growth factor β2 (TGF-β2) in the pathogenesis of systemic sclerosis (SSc) was investigated by in situ hybridization of skin biopsies from six patients with SSc. Two patients with acute systemic lupus erythematosus (SLE), one with acute dermatomyositis (DM), and three healthy individuals were used as controls. TGF-β2 mRNA was found to be co-localized with proα1(I) collagen expression around dermal blood vessels in all patients with the inflammatory stage of SSc, whereas there was no expression of either gene in the dermis of patients in the fibrotic stage, the SLE patients or the normal controls. These findings provide evidence that TGF-β2 released by inflammatory cells around blood vessels may play a role in mediating the collagen gene disregulation in fibrosis.

引用

页码：917 / 922

页数：6

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