CORTICAL GLUCOSE-METABOLISM IN HUNTINGTONS-DISEASE

被引：88

作者：

MARTIN, WRW

CLARK, C

AMMANN, W

STOESSL, AJ

SHTYBEL, W

HAYDEN, MR

机构：

[1] UNIV ALBERTA,DEPT MED NEUROL,EDMONTON T6G 2E1,ALBERTA,CANADA

[2] ST JOSEPHS HOSP,DIV NEUROL,LONDON N6A 4V2,ONTARIO,CANADA

[3] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,VANCOUVER V6T 1W5,BC,CANADA

[4] UNIV BRITISH COLUMBIA,DEPT RADIOL NUCL MED,VANCOUVER V6T 1W5,BC,CANADA

[5] UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER V6T 1W5,BC,CANADA

来源：

NEUROLOGY | 1992年 / 42卷 / 01期

关键词：

D O I：

10.1212/WNL.42.1.223

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We measured cortical glucose metabolism with positron emission tomography in 39 patients with Huntington's disease (HD) and in 34 controls. In the 23 patients with symptoms for less than 5 years, there was a 15% decrease in metabolism in frontal and inferior parietal cortex. In 16 patients with symptoms for more than 5 years, all cortical areas (except temporal) were significantly involved, with metabolic rates 25 to 30% below those of controls. These data indicate the presence of a diffuse abnormality of cortical function with early involvement of frontal lobes in HD, suggesting that the clinical manifestations may not be related solely to basal ganglia pathology, even in early disease.

引用

页码：223 / 229

页数：7

共 45 条

[1] CROSSED CEREBELLAR AND UNCROSSED BASAL GANGLIA AND THALAMIC DIASCHISIS IN ALZHEIMERS-DISEASE [J].