ENDOTHELIN-3 INCREASES TRANSMISSION IN THE RABBIT PULMONARY PARASYMPATHETIC NERVOUS-SYSTEM

被引：24

作者：

MCKAY, KO

ARMOUR, CL

BLACK, JL

机构：

[1] UNIV SYDNEY,DEPT PHARMACOL,SYDNEY,NSW 2006,AUSTRALIA

[2] UNIV SYDNEY,DEPT PHARM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1993年 / 22卷

关键词：

ENDOTHELIN-3; RABBIT AIRWAYS; PARASYMPATHETIC NERVOUS SYSTEM; NEUROMODULATION;

D O I：

10.1097/00005344-199322008-00049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of endothelin-3 (ET-3) on the response to parasympathetic nerve stimulation of rabbit isolated bronchus was examined. The site of action of ET-3 in the pulmonary parasympathetic nervous system was also investigated. ET-3 induced a concentration-dependent increase in the response to electrical field stimulation. The response was atropine sensitive and therefore cholinergically mediated. At a concentration of 10 nM, ET-3 increased the response to field stimulation to 205 +/- 42% of the initial response. The effect was concentration-related, as 100 nM further increased this response to 315 +/- 69%. The responsiveness of the tissue to exogenous acetylcholine was not affected by ET-3. Therefore ET-3 has a neuromodulatory role on cholinergic parasympathetic transmission in rabbit airways exerted at a prejunctional site.

引用

页码：S181 / S184

页数：4

共 11 条

[1] NEDOCROMIL SODIUM INHIBITS SUBSTANCE P-INDUCED POTENTIATION OF CHOLINERGIC NEURAL RESPONSES IN THE ISOLATED INNERVATED RABBIT TRACHEA [J].