ENHANCED INFLAMMATORY REACTIVITY IN THE PATHOGENESIS OF SPONDYLOARTHROPATHIES

被引：5

作者：

REPO, H

RISTOLA, M

LEIRISALOREPO, M

机构：

[1] Department of Bacteriology and Immunology, University of Helsinki, SF-00290, Helsinki

[2] Second Department of Medicine, University of Helsinki, SF-00290, Helsinki

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 04期

关键词：

HLA-B27; Inflammation; Reactive arthritis; Spondyloarthropathy;

D O I：

10.3109/08916939009087584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pathogenesis of seronegative spondyloarthropathies such as ankylosing spondylitis and reactive arthritis is not known. Growing evidence indicates that microbial structures such as Chlamydia antigen and Yersinia antigen are present in the inflamed joints of patients with reactive arthritis. Microbial antigens can activate the host's inflammatory mechanisms. After the activation, the course of inflammation can be postulated to be affected by the host factors responsible for amplification of the inflammatory reaction and elimination of the foreign structures. Thus, the amplification, whether strong, moderate, or weak, may contribute to the degree of inflammatory tissue injury in patients with seronegative spondyloarthropathies. This review will discuss the role of increased inflammatory reactivity in the pathogenesis of HLA-B27 associated spondyloarthropathies, with special reference to reactive arthritis triggered by yersinia enteritis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：245 / 254

页数：10

共 55 条

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