CHEMOENZYMATIC SYNTHESIS AND FUNGICIDAL ACTIVITY OF THE 4 PURE STEREOISOMERS OF A NEW MORPHOLINE DERIVATIVE

被引：7

作者：

BIANCHI, D

CESTI, P

GOLINI, P

SPEZIA, S

FILIPPINI, L

GARAVAGLIA, C

MIRENNA, L

机构：

[1] Istituto Guido Donegani, 28100 Novara

[2] Enichem Agricoltura-Ricerche Fitofarmaci, 28100 Novara

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1992年 / 40卷 / 10期

关键词：

D O I：

10.1021/jf00022a051

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Four optically pure stereoisomers of 2,6-dimethyl-4-[2-methyl-3-[3-(cyclopropyhnethoxy)phenyl]propyl]-morpholine (1), a new broad-spectrum morpholine fungicide, were prepared starting from the chiral precursor 2-methyl-3-[3-(benzyloxy)phenyl]-1-propanol(2). Optically active 2 was obtained by lipase-catalyzed kinetic resolution of (R,S)-2 and by stereoselective bakers' yeast reduction of 2-methyl-3-[3-(benzoyloxy)phenyl]propenal (4). The biological activity of the pure stereoisomers has been evaluated in vitro against a variety of fungi and in vivo against Erysiphe graminis on wheat and Helminthosporium teres on barley.

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页码：1989 / 1992

页数：4

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