CEREBRAL BLOOD-FLOW AND INDOMETHACIN DRUG LEVELS IN SUBJECTS WITH AND WITHOUT CENTRAL NERVOUS SIDE-EFFECTS

被引：26

作者：

SEIDEMAN, P

VONARBIN, M

机构：

[1] Department of Internal Medicine, Karolinska Institutet, Danderyd

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 04期

关键词：

INDOMETHACIN; CENTRAL NERVOUS SYSTEM; SIDE-EFFECTS; BLOOD CONCENTRATIONS; CEREBRAL BLOOD FLOW;

D O I：

10.1111/j.1365-2125.1991.tb05558.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Central nervous system (CNS) side effects are observed during treatment with all nonsteroidal anti-inflammatory drugs (NSAIDs) but their effects are more common during treatment with indomethacin. 2 The aim of the study was to elucidate the mechanism of the CNS related side effects of indomethacin. Two groups were obtained, one with (n = 11), and one without (n = 7), CNS symptoms. Cerebral blood flow was measured in these groups with Doppler equipment, indomethacin levels with h.p.l.c. and CNS symptoms graded on a VAS scale. 3 Blood flow was reduced by 18-30% and was most marked 60 min after dose and did not differ between the two groups. The maximum CNS effect coincided with indomethacin peak levels 60-70 min after dose. These results could implicate that CNS symptoms may be related to indomethacin levels in sensitive patients.

引用

页码：429 / 432

页数：4

共 19 条

[1] EFFECTS OF INDOMETHACIN ON REGIONAL BLOOD-FLOW IN CONSCIOUS RABBITS - MICROSPHERE STUDY [J].