EFFECTS OF PHYSOSTIGMINE ON SPATIAL ATTENTION IN PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY

被引:29
作者
KERTZMAN, C
ROBINSON, DL
LITVAN, I
机构
[1] NEI,SENSORIMOTOR RES LAB,VISUAL BEHAV SECT,BLDG 10,ROOM 10C101,BETHESDA,MD 20892
[2] NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892
关键词
D O I
10.1001/archneur.1990.00530120092016
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We tested patients with progressive supranuclear palsy and control subjects on a task of visuospatial attention. Targets preceded by cues on the same side were termed validly cued; and those on the opposite side, invalidly cued. For all subjects, validly cued targets were responded to faster than those that were invalidly cued. The difference between reaction times for invalidly and validly cued targets, which is hypothesized to measure attentional movement, was significantly increased for the patients. The performance of the controls on certain neuropsychological tests was correlated with their attentional ability. These correlations were altered by progressive supranuclear palsy. Physostigmine treatment of the patients induced a speeding of responses to invalidly cued targets as a function of the duration of the disease. These studies show defects in cognition and attention in patients with progressive supranuclear palsy and demonstrate that physostigmine reduces some of the abnormal visual attentional performance. © 1990, American Medical Association. All rights reserved.
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页码:1346 / 1350
页数:5
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