ENDOTHELIUM-DERIVED RELAXING FACTOR IS A NITROSYL IRON COMPLEX WITH THIOL LIGANDS

被引：132

作者：

VANIN, AF

机构：

[1] Institute of Chemical Physics, Academy of Sciences, USSR, 117334 Moscow

来源：

FEBS LETTERS | 1991年 / 289卷 / 01期

关键词：

ENDOTHELIUM-DERIVED RELAXING FACTOR; NITRIC OXIDE; NITROSYL NONHEME IRON COMPLEX; FREE IRON;

D O I：

10.1016/0014-5793(91)80894-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hypothesis is put forward on the nature of the endothelium-derived relaxing factor (EDRF) which is released from vascular endothelial cells by acetylcholine, bradykinin and other agonists. It is suggested that EDRF is a nitrosyl iron complex with low-molecular thiol ligands, most probably with cysteine. Its active principle is nitric oxide (NO). This free radical is stabilized by inclusion into the iron complex, which promotes NO transfer within the cell and between cells. Subsequent release of NO from these complexes results from thiol group oxidation.

引用

页码：1 / 3

页数：3

共 54 条

[1] NITRIC-OXIDE ACTIVATES GUANYLATE CYCLASE AND INCREASES GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE LEVELS IN VARIOUS TISSUE PREPARATIONS [J].