QT-INTERVAL ABNORMALITIES IN HYPERTROPHIC CARDIOMYOPATHY

被引:82
作者
DRITSAS, A
SBAROUNI, E
GILLIGAN, D
NIHOYANNOPOULOS, P
OAKLEY, CM
机构
[1] Department of Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, Clinical Cardiology, London
关键词
HYPERTROPHIC CARDIOMYOPATHY; QT INTERVAL;
D O I
10.1002/clc.4960151010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To examine whether QTc and QTc dispersion across the leads of a surface electrocardiogram (ECG) are different in patients with hypertrophic cardiomyopathy (HCM) compared with normal subjects, we measured QT and calculated QTc in all 12 leads of a surface ECG in 24 patients with HCM and in 20 age- and sex-matched normal control subjects. Maximal QTc was prolonged in HCM patients (465 +/- 24 ms) compared with controls (410 +/- 20 ms) (p < 0.001). QTc dispersion defined as the difference of maximum-minimum QTc was also greater in HCM patients (71 +/- 21 ms) compared with normals (35 +/- 11 ms) (p < 0.001). A correlation was found between the degree of left ventricular hypertrophy expressed by the maximal wall thickness and maximal QTc (r = 0.48, p < 0.02). However, QTc dispersion did not correlate with maximal wall thickness. Thus, patients with HCM show a prolonged QTc (> 440 ms) and increased QTc dispersion compared with normal subjects. In addition, the degree of left ventricular hypertrophy correlates with maximal QTc. The presence of a prolonged QT with increased regional dispersion may be associated with the occurrence of serious ventricular arrhythmia and sudden death in HCM.
引用
收藏
页码:739 / 742
页数:4
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