SYNTHESIS OF STEROIDAL D-RING FUSED PYRAZOLINES - STUDY OF REGIOCHEMISTRY OF ADDITION

被引：16

作者：

GREEN, B

SHEU, KY

机构：

[1] Department of Chemistry, University of Maine, Orano, ME

来源：

STEROIDS | 1994年 / 59卷 / 08期

关键词：

D-RING ADDITION; DIARYLPYRAZOLINES; DIPHENYLNITRILIMINES; REGIOCHEMISTRY;

D O I：

10.1016/0039-128X(94)90061-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The addition of diphenylnitrilimine and C-o-chlorodiphenylnitrilimine to 3 beta-hydroxyandrost-5,16-diene (3b) produced a 1/1 ratio of regioisomeric, 1,3-diaryl-2-pyrazolines (6a, 7a and 6b, 7b), whereas the addition of N-o-chlorodiphenylnitrilimine gave a 5/1 ratio in favor of the [17 alpha,16 alpha-d] regioisomer (7c). To further delineate the factors governing the regiochemistry of addition of diphenylnitrilimines to steroid 16-enes, additions were carried out on 16-acetyl-5 alpha-androst-16-ene (5b) and 1-acetylcyclopentene (10).

引用

页码：479 / 484

页数：6

共 15 条

[1]

A NEW REACTION OF HYDRAZONES [J].