CHARACTERIZATION OF ZYMOSAN-INDUCED ARTHRITIS IN THE RAT - EFFECTS ON JOINT INFLAMMATION AND CARTILAGE METABOLISM

被引：37

作者：

GEGOUT, P ^{[1
]}

GILLET, P ^{[1
]}

CHEVRIER, D ^{[1
]}

GUINGAMP, C ^{[1
]}

TERLAIN, B ^{[1
]}

NETTER, P ^{[1
]}

机构：

[1] UNIV HENRI POINCARE NANCY 1, FAC MED,DEPT PHARMACOL,PHARMACOL LAB,CNRS, URA 1288, F-54505 VANDOEUVRE LES NANCY, FRANCE

来源：

LIFE SCIENCES | 1994年 / 55卷 / 17期

关键词：

ZYMOSAN; ARTICULAR CARTILAGE; EXPERIMENTAL ARTHRITIS; INTERLEUKIN-1;

D O I：

10.1016/0024-3205(94)00771-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A single intra-articular (ia) injection of 2 mg zymosan on DO led to the production of acute periarticular edema followed by subacute erosive synovitis. The development of the zymosan-induced arthritis was associated with an initial loss of running activity and with an initial decrease of proteoglycan synthesis. Febrile response was present only on D1. In addition, on D20 synovial pannus led to a marked depletion of the proteoglycan content in the articular cartilage. When injected ia, IL1 beta (1 mu g) provoked similar fever and similar changes in cartilage anabolism, but did not affect cartilage proteoglycan content (D20). These results suggest that zymosan-induced synovitis in the rat combines early prostaglandin-dependent processes (edema, pain, fever) with IL1-related effects on cartilage metabolism, thus allowing evaluation of chondroprotective drugs.

引用

页码：PL321 / PL326

页数：6

共 15 条

[1] INHIBITION OF SYNOVIAL-LTB(4) PRODUCTION BY A SPECIFIC LEUKOTRIENE BIOSYNTHESIS INHIBITOR, MK-0591, IN A RABBIT MODEL OF JOINT INFLAMMATION [J].