DETERMINATION OF COMPOUNDS WITH ANTICHOLINESTERASE ACTIVITY IN COMMERCIAL DRUGS BY A NEW ENZYME SENSOR

被引：15

作者：

CAMPANELLA, L

COCCO, R

TOMASSETTI, M

机构：

[1] Dipartimento di Chimica, Università di Roma 'La Sapienza', 00185 Roma, P. le Aldo Moro

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 10-12期

关键词：

BIOSENSOR; ANTICHOLINESTERASE DRUGS; ANALYSIS;

D O I：

10.1016/0731-7085(91)80074-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A suitable enzyme sensor for the analysis of anticholinesterase compounds of pharmaceutical interest is described. It is based on the competitive inhibiting properties of these compounds on the enzyme butyrylcholinesterase and it is constituted by a hydrogen peroxide amperometric electrode modified by a superimposed Nylon membrane containing two chemically immobilized biological mediators (butyrylcholinesterase and choline oxidase). Some applications to the analysis of several pharmaceutical forms containing different compounds showing anticholinesterase activity are also reported and evaluated.

引用

页码：741 / 749

页数：9

共 14 条

[1]

ACHILLI M, 1990, INQUINAMENTO NOV, P66

[2]

BERNABEI B, 1990, 9 C NAZ DIV CHIM ANA, P236

[3]

BOWMAN WC, 1985, FARMACOLOGIA

[4] BUTYRYLCHOLINE ENZYME SENSOR FOR DETERMINING ORGANOPHOSPHORUS INHIBITORS [J].