INTERLEUKIN-1-BETA DECREASES ACETYLCHOLINE MEASURED BY MICRODIALYSIS IN THE HIPPOCAMPUS OF FREELY MOVING RATS

被引：118

作者：

RADA, P

MARK, GP

VITEK, MP

MANGANO, RM

BLUME, AJ

BEER, B

HOEBEL, BG

机构：

[1] PRINCETON UNIV,DEPT PSYCHOL,PRINCETON,NJ 08544

[2] AMER CYANAMID CO,LEDERLE LABS,MOLEC NEUROBIOL GRP,PEARL RIVER,NY 10965

来源：

BRAIN RESEARCH | 1991年 / 550卷 / 02期

关键词：

INTERLEUKIN-1-BETA; HIPPOCAMPUS; MICRODIALYSIS; ALZHEIMERS DISEASE; ACETYLCHOLINE;

D O I：

10.1016/0006-8993(91)91330-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute response in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1-beta (7.5-50-mu-g/kg) decreased extracellular acetylcholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

引用

页码：287 / 290

页数：4

共 24 条

[1] BIDIRECTIONAL TRANSPORT OF INTERLEUKIN-1-ALPHA ACROSS THE BLOOD-BRAIN-BARRIER [J].