ALTERED AMBULATORY ACTIVITY AND RELATED BRAIN MONOAMINE METABOLISM IN GENETICALLY-OBESE ZUCKER RATS

被引：11

作者：

SHIMIZU, H

SHIMOMURA, Y

TAKAHASHI, M

UEHARA, Y

FUKATSU, A

SATO, N

机构：

[1] First Department of Internal Medicine, Gunma University School of Medicine, Maebashi/Japan

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY | 1991年 / 97卷 / 01期

关键词：

GENETIC OBESITY; AMBULATORY ACTIVITY; MONOAMINE; RAT;

D O I：

10.1055/s-0029-1211036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Feeding-related behavior and alteration of brain monoamine metabolism were examined in the male lean, and obese Zucker rats. Ambulatory activity of obese rats was reduced in the dark cycle. Dopamine (DA) and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), contents were significantly decreased in the striatum of obese rats. However, the metabolic rate assessed with the DOPAC/DA ratio, and norepinephrine (EN) content were not changed in the striatum. Hypothalamic DA and NE contents were significantly reduced and the DOPAC/DA ratio was significantly increased in the hypothalamus of obese rats. The present findings suggest that the observed changes in brain monoamine metabolism may contribute to the development of obesity reducing ambulatory activity of obese rats.

引用

页码：39 / 44

页数：6

共 15 条

[1] LONG-TERM ADMINISTRATION OF SOME ANTIPSYCHOTIC-DRUGS INCREASES BODY-WEIGHT AND FEEDING IN RATS - ARE D2 DOPAMINE-RECEPTORS INVOLVED [J].