CHROMATID-TYPE ABERRATIONS INDUCED BY ALUI IN CHINESE-HAMSTER OVARY CELLS

被引：7

作者：

OBE, G ^{[1
]}

JOHANNES, C ^{[1
]}

WERTHMANN, I ^{[1
]}

FOLLE, GA ^{[1
]}

机构：

[1] INST INVEST BIOL CLEMENTE ESTABLE,DIV HUMAN CYTOGENET & QUANTITAT MICROSCOPY,MONTEVIDEO 11600,URUGUAY

来源：

MUTATION RESEARCH | 1993年 / 299卷 / 3-4期

关键词：

ALUI; CHROMATID-TYPE ABERRATION INDUCTION; CHO CELLS;

D O I：

10.1016/0165-1218(93)90107-O

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Treatment of CHO cells with AluI in the S-phase leads to chromatid-type aberrations whose frequencies are linearly correlated with dose. Treatment in the S-phase leads to fewer aberrations than treatment in the G1-phase, which is comparable to chromosomal aberration induction following X-irradiation in the G1- and S-phases. Treatment in the G1-phase leads to few chromatid-type interchanges, some of these may originate from DNA single-strand gaps induced by AluI in canonical structures of DNA and in DNA - RNA hybrids.

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页码：305 / 311

页数：7

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