AN HSP60 RELATED PROTEIN IS ASSOCIATED WITH PURIFIED HIV AND SIV

被引：27

作者：

BARTZ, SR

PAUZA, CD

IVANYI, J

JINDAL, S

WELCH, WJ

MALKOVSKY, M

机构：

[1] UNIV WISCONSIN,SCH MED,DEPT MED MICROBIOL & IMMUNOL,1300 UNIV AVE,MADISON,WI 53706

[2] PERSEPT BIOSYST INC,CAMBRIDGE,MA

[3] UNIV WISCONSIN,DEPT PATHOL,MADISON,WI 53706

[4] UNIV WISCONSIN,DEPT HUMAN ONCOL,MADISON,WI 53706

[5] UNIV WISCONSIN,WISCONSIN REG PRIMATE RES CTR,MADISON,WI 53706

[6] MRC,TB & RELATED INFECT UNIT,LONDON WC1E 6AS,ENGLAND

[7] UNIV CALIF SAN FRANCISCO,DEPT MED & PHYSIOL,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

HEAT SHOCK PROTEINS; IMMUNODEFICIENCY VIRUSES;

D O I：

10.1111/j.1600-0684.1994.tb00116.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The possible physical association of heat shock proteins (Hsp's) with immunodeficiency viruses (HIV and SIV) has been examined. The virions were purified by a) polyethylene glycol (PEG) precipitation and Sepharose 4B filtration, b) PEG precipitation and centrifugation over a Renografin gradient, or c) PEG precipitation and Matrex Cellufine Sulfate affinity chromatography. Western blotting revealed an Hsp60 related protein associated with HIV and SIV. Other Hsp's (such as Hsp70) were not detected, suggesting a specific interaction between Hsp60 and viral factors.

引用

页码：151 / 154

页数：4

共 38 条

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