A FACILE SYNTHESIS OF OPTICALLY-ACTIVE C-2-SYMMETRICAL 2,5-DISUBSTITUTED PYRROLIDINES AND OTHER BETA,BETA'-DIHYDROXYAMINES

被引：31

作者：

KOH, K ^{[1
]}

BEN, RN ^{[1
]}

DURST, T ^{[1
]}

机构：

[1] UNIV OTTAWA,OTTAWA CARLETON CHEM INST,DEPT CHEM,OTTAWA K1N 6N5,ON,CANADA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期

关键词：

D O I：

10.1016/0040-4039(94)85057-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,5-Dibromoadipic acid has been converted into the di-(R)-pantolactone ester of (S,S)-pyyrolidine-2,5-dicarboxylic acid in two steps. This compound serves ar a precursor to C-2-symmetric 2,5-disubstituted pyrrolidines. The synthesis of linear C-2-symmetric beta,beta'-dihydroxyamines starting with alpha-bromophenylacetic acid and (S)-phenylglycine ethyl ester is also reported.

引用

页码：375 / 378

页数：4

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