BEHAVIORAL AND ELECTROPHYSIOLOGICAL CORRELATES OF THE QUINOLINIC ACID RAT MODEL OF HUNTINGTONS-DISEASE IN RATS

被引：34

作者：

POPOLI, P

PEZZOLA, A

DOMENICI, MR

SAGRATELLA, S

DIANA, G

CAPORALI, MG

BRONZETTI, E

VEGA, J

DECAROLIS, AS

机构：

[1] UNIV ROMA LA SAPIENZA, DEPT CARDIOVASC & RESP SCI, ROME, ITALY

[2] FAC MED OVIEDO, DEPT MORPHOL & CELLULAR BIOL, OVIEDO, SPAIN

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 35卷 / 04期

关键词：

QUINOLINE ACID; HUNTINGTONS DISEASE; EEG; MOTOR ACTIVITY; MORRIS MAZE; HIPPOCAMPAL ELECTROPHYSIOLOGY; RAT;

D O I：

10.1016/0361-9230(94)90109-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of bilateral intrastriatal injection of quinolinic acid (QA, 300 nmol) was studied in male Wistar rats. Behavioral and electrophysiological experiments were conducted in 15 lesioned plus 15 vehicle-injected (control) animals. With respect to control animals, QA-lesioned rats showed marked, statistically significant alterations from both the behavioral (greater motor activation in response to d-amphetamine, plate-learning deficit in the Morris water maze), and the electroencephalographic (reduced voltage amplitude and EEG power at the level of frontal cortex) points of view. In addition, a significant loss in body weight and a marked striatal gliosis (GFAP staining) were observed in lesioned rats. Conversely, QA-lesioned rats did not show modifications in posttetanic potentiation (P.T.P.) or long-term potentiation (L.T.P.) in CAI hippocampal area. The present results confirm that QA lesions of rat striatum may be regarded as a suitable model of Huntington's disease (HD).

引用

页码：329 / 335

页数：7

共 48 条

[1] ABNORMALITIES OF PARIETAL AND PREROLANDIC SOMATOSENSORY EVOKED-POTENTIALS IN HUNTINGTONS-DISEASE [J].