IMMUNOGENETICS OF MYCOBACTERIAL INFECTIONS - MOUSE-HUMAN HOMOLOGIES

被引：30

作者：

SCHURR, E ^{[1
]}

BUSCHMAN, E ^{[1
]}

MALO, D ^{[1
]}

GROS, P ^{[1
]}

SKAMENE, E ^{[1
]}

机构：

[1] MONTREAL GEN HOSP,MCGILL CTR STUDY HOST RESISTANCE,1650 CEDAR AVE,ROOM 7113,MONTREAL H3G 1A4,QUEBEC,CANADA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 04期

关键词：

D O I：

10.1093/infdis/161.4.634

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the mouse, innate resistance or susceptibility to infection with numerous mycobacteria is controlled by the Bcginf host resistance locus located on the centromeric region of chromosome 1. The resistance/susceptibility phenotype is expressed by the mature tissue macrophage and Bcginf has been identified as a locus that is involved in the regulation of macrophage activation and in the modulation of acquired immune responses to mycobacteria. Experiments aimed at the cloning of the Bcginf gene via a “reverse genetics” approach have generated a detailed genetic map in the immediate vicinity of the locus, placing Bcginf within the reach of long-range eukaryotic cloning techniques. The chromosomal segment around Bcginf in the mouse is exactly conserved onto the long arm (q) ofhuman chromosome 2. Linkage of genetic markers from human chromosome 2q with susceptibility to leprosy or tuberculosis would support both the existence of a susceptibility gene in humans and the contention that this susceptibility gene is a homologue of the mouse Bcginf locus. © 1990, University of Chicago. All rights reserved.

引用

页码：634 / 639

页数：6

共 59 条

[1] ABEL L, 1988, AM J HUM GENET, V42, P256
[2] MOLECULAR TRANSDUCTIONAL MECHANISMS BY WHICH IFN-GAMMA AND OTHER SIGNALS REGULATE MACROPHAGE DEVELOPMENT
ADAMS, DO
HAMILTON, TA
[J]. IMMUNOLOGICAL REVIEWS, 1987, 97 : 5 - 27
[3] BLACKWELL JM, 1988, CURR TOP MICROBIOL, V137, P301
[4] BLOOM BR, 1983, REV INFECT DIS, V5, P765
[5] BROWN IN, 1982, IMMUNOLOGY, V47, P149
[6] GENETIC-ASPECTS OF INNATE RESISTANCE AND ACQUIRED-IMMUNITY TO MYCOBACTERIA IN INBRED MICE
BUSCHMAN, E
APT, AS
NICKONENKO, BV
MOROZ, AM
AVERBAKH, MH
SKAMENE, E
[J]. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1988, 10 (04): : 319 - 336
[7] IMMUNOLOGICAL CONSEQUENCES OF INNATE RESISTANCE AND SUSCEPTIBILITY TO BCG
BUSCHMAN, E
SKAMENE, E
[J]. IMMUNOLOGY LETTERS, 1988, 19 (03) : 199 - 210
[8] BUSCHMAN E, IN PRESS IMMUNOL RES
[9] CHAKRAVARTTI MR, 1973, TOPIC HUMAN GENETICS, V2, P1
[10] COMSTOCK GW, 1978, AM REV RESPIR DIS, V117, P621

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