CHARACTERIZATION OF THE 5' FLANKING REGION OF THE RAT NA+/K+-ATPASE BETA-1 SUBUNIT GENE

被引：29

作者：

LIU, B ^{[1
]}

GICK, G ^{[1
]}

机构：

[1] SUNY HLTH SCI CTR,DEPT BIOCHEM,450 CLARKSON AVE,BROOKLYN,NY 11203

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 03期

关键词：

ATPASE; NA+/K+-; BETA-1; SUBUNIT; 5' FLANKING SEQUENCE; (RAT);

D O I：

10.1016/0167-4781(92)90449-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated the 5' end of the rat Na+/KA+-ATPase beta-1 subunit gene. A genomic fragment containing 817 bp of the 5' flanking sequence, exon 1 and 479 bp of intron 1 was sequenced. The 5' flanking region contains a potential TATA box and several putative CAAT and GC boxes. Potential binding sites for thyroid and glucocorticoid receptors were identified together with multiple sequence motif's which exhibit homology to calcium and serum responsive elements.

引用

页码：336 / 338

页数：3

共 11 条

[1] GENE-REGULATION BY STEROID-HORMONES [J].

BEATO, M .

CELL, 1989, 56 (03) :335-344

[2] INDUCTION OF NA+-K+-ATPASE AND ITS SUBUNIT MESSENGER-RNAS BY SERUM IN A RAT-LIVER CELL-LINE [J].

BHUTADA, A ;

PEREZ, C ;

CHON, DY ;

ISMAILBEIGI, F .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (06) :C1044-C1050

[3] THE SARCOMERIC ACTIN CARG-BINDING FACTOR IS INDISTINGUISHABLE FROM THE C-FOS SERUM RESPONSE FACTOR [J].

BOXER, LM ;

PRYWES, R ;

ROEDER, RG ;

KEDES, L .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) :515-522

[4] ABUNDANCE OF NA+-K+-ATPASE MESSENGER-RNA IS REGULATED BY GLUCOCORTICOID HORMONES IN INFANT RAT KIDNEYS [J].

CELSI, G ;

NISHI, A ;

AKUSJARVI, G ;

APERIA, A .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02) :F192-F197

[5]

GICK GG, 1988, J BIOL CHEM, V263, P16610

[6] CHARACTERIZATION OF 2 GENES FOR THE HUMAN NA,K-ATPASE BETA-SUBUNIT [J].

LANE, LK ;

SHULL, MM ;

WHITMER, KR ;

LINGREL, JB .

GENOMICS, 1989, 5 (03) :445-453

[7] THE ORIENTATION AND SPACING OF CORE DNA-BINDING MOTIFS DICTATE SELECTIVE TRANSCRIPTIONAL RESPONSES TO 3 NUCLEAR RECEPTORS [J].

NAAR, AM ;

BOUTIN, JM ;

LIPKIN, SM ;

YU, VC ;

HOLLOWAY, JM ;

GLASS, CK ;

ROSENFELD, MG .

CELL, 1991, 65 (07) :1267-1279

[8]

RAYSON BM, 1991, J BIOL CHEM, V266, P21335

[9] CALCIUM AND GROWTH-FACTOR PATHWAYS OF C-FOS TRANSCRIPTIONAL ACTIVATION REQUIRE DISTINCT UPSTREAM REGULATORY SEQUENCES [J].

SHENG, M ;

DOUGAN, ST ;

MCFADDEN, G ;

GREENBERG, ME .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (07) :2787-2796

[10] DIRECT REPEATS AS SELECTIVE RESPONSE ELEMENTS FOR THE THYROID-HORMONE, RETINOIC ACID, AND VITAMIN-D3 RECEPTORS [J].

UMESONO, K ;

MURAKAMI, KK ;

THOMPSON, CC ;

EVANS, RM .

CELL, 1991, 65 (07) :1255-1266

← 1 2 →