DIFFERENTIAL EXPRESSION OF THE CD44 MOLECULE IN HUMAN BRAIN-TUMORS

被引：132

作者：

KUPPNER, MC

VAN MEIR, E

GAUTHIER, T

HAMOU, MF

DETRIBOLET, N

机构：

[1] Neurosurgical Service, University Hospital, Lausanne

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 50卷 / 04期

关键词：

D O I：

10.1002/ijc.2910500414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of the CD44 molecule was examined in a variety of human brain tumours, brain metastases and normal brain. Immunohistological staining with several CD44 antibodies demonstrated differential expression of the CD44 molecule among different brain tumour types. CD44 was strongly expressed in high-grade gliomas and weakly expressed in meningiomas, medulloblastomas and normal brain. Northern blot analysis revealed the presence of 3 major CD44 mRNAs of 1.6, 2.2, and 5.0 kb in glioblastomas and a mRNA of 5.6 kb in meningiomas. CD44 expression was also detected by flow cytometric analysis on cultured cells derived from a variety of human brain tumours including glioblastomas and meningiomas.

引用

页码：572 / 577

页数：6

共 22 条

[1] THE HYALURONATE RECEPTOR IS PREFERENTIALLY EXPRESSED ON PROLIFERATING EPITHELIAL-CELLS
ALHO, AM
UNDERHILL, CB
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (04) : 1557 - 1565
[2] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE
ARUFFO, A
STAMENKOVIC, I
MELNICK, M
UNDERHILL, CB
SEED, B
[J]. CELL, 1990, 61 (07) : 1303 - 1313
[3] GLYCOSAMINOGLYCAN CHANGES IN HUMAN GLIOMAS - A BIOCHEMICAL-STUDY
BERTOLOTTO, A
MAGRASSI, ML
ORSI, L
SITIA, C
SCHIFFER, D
[J]. JOURNAL OF NEURO-ONCOLOGY, 1986, 4 (01) : 43 - 48
[4] CARTER WG, 1988, J BIOL CHEM, V263, P4193
[5] INDUCTION AND DETECTION OF A HUMAN-ENDOTHELIAL ACTIVATION ANTIGEN INVIVO
COTRAN, RS
GIMBRONE, MA
BEVILACQUA, MP
MENDRICK, DL
POBER, JS
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (02) : 661 - 666
[6] FLANAGAN BF, 1989, IMMUNOLOGY, V67, P167
[7] STRUCTURAL HOMOLOGY BETWEEN LYMPHOCYTE RECEPTORS FOR HIGH ENDOTHELIUM AND CLASS-III EXTRACELLULAR-MATRIX RECEPTOR
GALLATIN, WM
WAYNER, EA
HOFFMAN, PA
STJOHN, T
BUTCHER, EC
CARTER, WG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) : 4654 - 4658
[8] HALE LP, 1989, J IMMUNOL, V143, P3944
[9] CD44 - A MOLECULE INVOLVED IN LEUKOCYTE ADHERENCE AND T-CELL ACTIVATION
HAYNES, BF
TELEN, MJ
HALE, LP
DENNING, SM
[J]. IMMUNOLOGY TODAY, 1989, 10 (12): : 423 - 428
[10] HAYNES BF, 1983, J IMMUNOL, V131, P1195

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