ISOLATION OF A HEMOGLOBIN-DERIVED OPIOID PEPTIDE FROM CEREBROSPINAL-FLUID OF PATIENTS WITH CEREBROVASCULAR BLEEDINGS

被引：100

作者：

GLAMSTA, EL

MEYERSON, B

SILBERRING, J

TERENIUS, L

NYBERG, F

机构：

[1] KAROLINSKA HOSP,DEPT NEUROSURG,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA INST,DEPT DRUG DEPENDENCE RES,S-10401 STOCKHOLM 60,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90699-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hemorphins are peptides with opioid activity, which are enzymatically released from hemoglobin. A decapeptide identical to the sequence 32-41 of the β-, δ-, γ- or ε{lunate}-chains of hemoglobin has been isolated from human ventricular cerebrospinal fluid (CSF). The peptide, designated LVV-hemorphin-7, was recovered in relatively high amounts (115-300 pmol per ml) from samples of patients with cerebrovascular bleedings, but was not detectable in control CSF. Its identity with the hemoglobin fragment was confirmed by mass spectrometry and gas-phase sequencing. © 1992.

引用

页码：1060 / 1066

页数：7

共 16 条

[1]

BRANTL V, 1983, TRENDS PHARMACOL SCI, V4, P193

[2] NOVEL OPIOID-PEPTIDES DERIVED FROM MITOCHONDRIAL CYTOCHROME-B - CYTOCHROPHINS [J].