RET ONCOGENE ACTIVATION IN HUMAN THYROID NEOPLASMS IS RESTRICTED TO THE PAPILLARY CANCER SUBTYPE

被引：333

作者：

SANTORO, M

CARLOMAGNO, F

HAY, ID

HERRMANN, MA

GRIECO, M

MELILLO, R

PIEROTTI, MA

BONGARZONE, I

DELLAPORTA, G

BERGER, N

PEIX, JL

PAULIN, C

FABIEN, N

VECCHIO, G

JENKINS, RB

FUSCO, A

机构：

[1] MAYO CLIN & MAYO FDN,DIV ENDOCRINOL,ROCHESTER,MN 55905

[2] MAYO CLIN & MAYO FDN,DIV INTERNAL MED & LAB GENET,ROCHESTER,MN 55905

[3] IST NAZL TUMORI,DIV ONCOL SPERIMENTALE A,I-20133 MILAN,ITALY

[4] HOP ANTIQUAILLE,SERV CHIRURG,ANAT PATHOL LAB,F-69321 LYONS 05,FRANCE

[5] HOP J COURMONT ST EUGENIE,CYTOL LAB,F-69310 PIERRE BENITE,FRANCE

[6] UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 89卷 / 05期

关键词：

CARCINOMA; GENE REARRANGEMENT; RET PROTOONCOGENE; TYROSINE KINASE; PTC;

D O I：

10.1172/JCI115743

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oncogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

引用

页码：1517 / 1522

页数：6

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