THE TRACE AMINES AND THEIR ACIDIC METABOLITES IN DEPRESSION - AN OVERVIEW

被引：53

作者：

DAVIS, BA

BOULTON, AA

机构：

[1] Neuropsychiatrie Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Sask.

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1994年 / 18卷 / 01期

关键词：

ANTIDEPRESSANT; DEPRESSION; DIET; MANIA; MARKERS; PHENYLALANINE; PHENYLETHYLAMINE; M-HYDROXYPHENYLACETIC; P-HYDROXYPHENYLACETIC; INDOLEACETIC; INHIBITOR; PHENYLACETIC; TRYPTAMINE; TRYPTOPHAN; M-TYRAMINE; P-TYRAMINE;

D O I：

10.1016/0278-5846(94)90022-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Davis, Bruce A. and Alan A. Boulton: The Trace Amines and Their Acidic Metabolites in Depression - An Overview Progr. Neuro-Psychopharmacol & Biol. Psychiat. 1994, 18(1): 17-45. 1. Investigations of the role of the trace amines (phenylethylamine, tryptamine, m- and p-tyramine) and their acidic metabolites (phenylacetic, indoleacetic, m- and p-hydroxyphenylacetic acids) in depression are reviewed. 2. The evidence for the phenylethylamine hypothesis of depression is mixed. 3. Reduced phenylacetic acid levels in urine, plasma and CSF and changes in those levels during treatment with antidepressants show potential as state markers for depression. 4. Impaired p-tyramine conjugation following a tyramine challenge may be a good trait marker for depression.

引用

页码：17 / 45

页数：29

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[2]

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