FAMILIAL PRIMARY HYPERPARATHYROIDISM COMPLICATED WITH WILMS-TUMOR

被引：51

作者：

KAKINUMA, A ^{[1
]}

MORIMOTO, I ^{[1
]}

NAKANO, Y ^{[1
]}

FUJIMOTO, R ^{[1
]}

ISHIDA, O ^{[1
]}

OKADA, Y ^{[1
]}

INOKUCHI, N ^{[1
]}

FUJIHIRA, T ^{[1
]}

ETO, S ^{[1
]}

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT INTERNAL MED 1,1-1 ISEIGAOKA,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 02期

关键词：

MULTIPLE ENDOCRINE NEOPLASIA; MEN; PARATHYROID CANCER; CEMENTIFYING JAW FIBROMA; PARATHYROID HORMONE;

D O I：

10.2169/internalmedicine.33.123

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.

引用

页码：123 / 126

页数：4

共 29 条

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