学术探索
学术期刊
新闻热点
数据分析
智能评审

EXPRESSION PATTERNS OF 2 HUMAN GENES-CODING FOR DIFFERENT RAB GDP-DISSOCIATION INHIBITORS (GDIS), EXTREMELY CONSERVED PROTEINS INVOLVED IN CELLULAR-TRANSPORT

被引：49
作者：
BACHNER, D
SEDLACEK, Z
KORN, B
HAMEISTER, H
POUSTKA, A
机构：
[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,MOLEK GENOMANAL ABT,D-69120 HEIDELBERG,GERMANY
[2] UNIV ULM,MED GENET ABT,D-89069 ULM,GERMANY
来源：
HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 04期
关键词：
D O I：
10.1093/hmg/4.4.701
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have analysed the expression patterns of two human genes coding for two different rab GDIs, rab GDI alpha/XAP-4 and rab GDI beta, proteins involved in the regulation of vesicle-mediated cellular transport. The gene sequences are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms. Although the sequence homology between the two human rab GDIs studied is very high, their expression patterns are completely different. The Northern blot analysis and in situ hybridization to sections of mouse embryos and postnatal tissues have revealed that the rab GDI alpha/XAP-4 is expressed predominantly in neural and sensory tissues and may thus serve a specific function in neural signal transmission. In contrast to rab GDI alpha/XAP-4, the human rab GDI beta is expressed ubiquitously.
引用
收藏
页码：701 / 708
页数：8
相关论文
共 29 条
[1]  
ASADA M, 1993, EMBL NUCLEOTIDE SEQU
[2]   ENHANCED EXPRESSION OF THE MURINE FMR1 GENE DURING GERM-CELL PROLIFERATION SUGGESTS A SPECIAL FUNCTION IN BOTH THE MALE AND THE FEMALE GONAD [J].
BACHNER, D ;
MANCA, A ;
STEINBACH, P ;
WOHRLE, D ;
JUST, W ;
VOGEL, W ;
HAMEISTER, H ;
POUSTKA, A .
HUMAN MOLECULAR GENETICS, 1993, 2 (12) :2043-2050
[3]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[4]   PROTEINS REGULATING RAS AND ITS RELATIVES [J].
BOGUSKI, MS ;
MCCORMICK, F .
NATURE, 1993, 366 (6456) :643-654
[5]   ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].
CHIRGWIN, JM ;
PRZYBYLA, AE ;
MACDONALD, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1979, 18 (24) :5294-5299
[6]   DETECTION OF MESSENGER-RNAS IN SEA-URCHIN EMBRYOS BY INSITU HYBRIDIZATION USING ASYMMETRIC RNA PROBES [J].
COX, KH ;
DELEON, DV ;
ANGERER, LM ;
ANGERER, RC .
DEVELOPMENTAL BIOLOGY, 1984, 101 (02) :485-502
[7]  
Davis L. G., 1986, BASIC METHODS MOL BI
[8]  
DESPREZ T, 1994, EMBL NUCLEOTIDE SEQU
[9]   A SMALL GTP-BINDING PROTEIN (G-PROTEIN) RECOGNIZED BY SMG P25A GDP DISSOCIATION INHIBITOR (GDI) IN HUMAN PLATELET MEMBRANES AND GDI FOR THIS SMALL G-PROTEIN IN HUMAN PLATELET CYTOSOL [J].
FUJIOKA, H ;
KIKUCHI, A ;
YOSHIDA, Y ;
KURODA, S ;
TAKAI, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 168 (03) :1244-1252
[10]   GDI1 ENCODES A GDP DISSOCIATION INHIBITOR THAT PLAYS AN ESSENTIAL ROLE IN THE YEAST SECRETORY PATHWAY [J].
GARRETT, MD ;
ZAHNER, JE ;
CHENEY, CM ;
NOVICK, PJ .
EMBO JOURNAL, 1994, 13 (07) :1718-1728
123